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Our results are validated by the finding that most genes previously reported in BM are differentially regulated herein.
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Another challenge for the work presented herein, was to create, validate, and characterize a tightly regulated, conditional, "tetracycline on" (called herein "+ATc") system in T. gondii that would stably modify gene expression, independent of promoter strength.
One may envisage that compartmentalized xylulose-5-monophosphate pathway enzymes would constitute novel functions which underwent positive selection, leading to a highly regulated peroxisomal pathway as observed herein, while leaving the PPP unaffected.
Zilliacus and colleagues have previously suggested that MTs can be regulated by PXR [38], and the data presented herein is consistent with such a scenario.
All transcripts referred to herein as being up or down regulated have passed this significance test and subsequent filtering.
Herein, we mapped the genes uniquely regulated by candidate miRNAs to GeneGo database for analysis of enriched signaling pathway and disease ontology [ 40– 40].
Similar to the findings of Puroshotham et al. and Walker et al. we herein also observed that SREBPs are regulated in a SIRT1-independent manner.
Herein, we determined the role of estrogen regulated miR-26 and its underlying molecular mechanisms associated with estrogen receptor (ER)+ breast cancer proliferation.
Results presented herein utilize a co-culture model with natively regulated secretion of human apoE by glia, the main endogenous source of apoE in the CNS.
Herein, we identified 1777 genes that were differentially regulated more than three-fold compared to the corresponding control group and mostly associated with immune and inflammatory responses.
Seventy five genes were shared between the two datasets, herein denoted "SND2∩Ko", ~79% of which were regulated in a consistent direction (Table 1).
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