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Moreover, it has become increasingly clear that miRNAs are integral elements in a number of crucial gene expression networks, acting in tightly regulated feedback loops that are often disrupted in cancer.
Prolactin interacts with its receptors to trigger paracrine signalling mechanisms through a highly regulated feedback mechanism involving JAK/STAT and map kinase activity, as well as other downstream targets, which in turn regulate proliferation and cell differentiation [ 14].
The controller consists of a DC motor, itself a part of a simple regulated feedback system, with a rigid beam/tip mass configuration attached to the motor shaft.
These factors exist in a tightly regulated feedback circuit in most tissues with expression, although the precise nature of co-operative regulation may differ between tissues [23].
Embryonic development is a complex, dynamic and highly regulated feedback process where cells actively respond to and exert control over their environment to form intact tissues, which results in functioning organ systems [1], [2].
Doubtless, the nature of the blood pressure control network, with its many components, regulated feedback loops, and interactions with numerous environmental factors, contributes to this difficulty.
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Thus, the germline may also regulate feedback circuits to dampen sex-biased expression.
In principle, inhibitory plasticity mechanisms in mature cortex could regulate feedback inhibition at the level of each disynaptic circuit (Kullmann et al. 2012).
Aspartate kinase (AK) is an enzyme which is tightly regulated through feedback control and responsible for the synthesis of 4-phospho-l-aspartate from l-aspartate.
Stern and Emlin [17] suggested a model in which autonomous organ growth is regulated by feedback from other growing organs.
Such candidate receptors may be regulated via feedback mechanisms by their ligands and it is possible that one of them is responding to UAG treatment.
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