CHIP levels were found to be downregulated in a dose-dependent manner in all three bladder cancer cell lines, suggesting a CHIP-regulated effect on proteasomal degradation of associated target proteins, such as Hsp90 and its clients.
The relationship between structure and insecticidal activity was analyzed to reveal a possible co-regulated effect of the chiral amino acid ester, halogen atom or cyano group, and trifluoroethyloxyl group of the skeleton structures of the title compounds, which will provide useful information for guiding the design and discovery of new RyRs activators and insecticidal agrochemicals.
Our data identify FAK- and/or adhesion-regulated effects on the choice of substrates phosphorylated by Src.
Because we implement a viability constraint that all genes must remain regulated, the effect of increasing the binding site length, at some point, is masked by the inability of pathways to lose any more binding sites.
To better characterise CCND1 regulation, the effect of regulated pVHL expression upon CCND1 protein expression was examined in RCC4/iVHL-HA and RCC4/iVA cells the former comprising an inducible wild-type VHL in a VHL minus background, the latter the control.
Interestingly, two members of the SMAD family (SMAD5 and SMAD6) were up-regulated (main effect of age) in adipose tissue of LL chickens (Additional file 3).
However, many of these mechanically regulated effects have only been studied in two-dimensional (2D) culture, often using materials that preclude three-dimensional (3D) cell studies such as polyacrylamide or poly(dimethylsiloxane) (PDMS).
"+" represents up-regulated effect; "-" represents down-regulated effect.
For example, the actual reaction "A→B with kinetic constant k" may be considered in the qualitative representation as "if A is high, B could be up-regulated", but the effect of parameter "k" is neglected.
Gene array analysis showed numerous other gene expressions, quite apart from those mentioned above that are significantly up- or down-regulated indicating the effect of recombinant NYVAC in infected DCs.
Several citric acid cycle and ATP synthesis proteins were down-regulated, so the effect of PACs-treatment on P. aeruginosa biofilm may also be partly due to an effect on bacterial metabolism.
