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Great progress has been made in recent years towards unraveling how changes in the regulation of juvenile hormone and vitellogenin underlie these adaptively regulated differences in phenotype [ 3, 6].
These higher variances will make trans regulated differences in expression between conditions much harder to detect than cis regulated differences and indirect trans harder than direct trans.
The combined data suggests that there might be an approximately 2 1 ratio of trans: cis regulated differences in gene expression.
Expression differences in cis regulated genes were found to have lower variances than those of trans regulated genes in this study, and several eQTL studies have found that cis regulated differences in transcription are larger than trans regulated differences [ 3].
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For example, it is not suitable for investigating readthrough in terminally differentiated tissues, or for investigating tissue- and/or developmentally-regulated differences in readthrough efficiency during the plant life-cycle.
We suggest that correlation is a meaningful measure of biological significance, especially when considering GWAS genes, because it is likely that the correlations reflect subtle genetically-regulated differences in expression that are associated with alterations in BMD.
Information regarding sexually dimorphic expression in the SI at a prepubescent stage is still lacking, and no information is currently available regarding sex-regulated differences in gene expression in the colon.
Among 36 HSP70s, 16 transcripts differed in expression level, with eight up-regulated and eight down-regulated, although the differences in expression were slight.
In that case, given a representative sample of least-regulated centers, the differences in quality may have been even greater.
Interestingly, a gene coding for BRI1 was down-regulated at EL 36 in 2007 but up-regulated in 2008 suggesting differences in perception of brassinosteroids due to different climatic conditions or eventually due to tissue specific expression.
A GO enrichment analysis of the regulated genes (Table S3) showed genotypic differences in regulation of calcium transport and in structure molecules, such as collagen or extracellular matrix in developing worms.
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