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The biology of elastic fibers is complex because they have multiple components, a tightly regulated developmental deposition, a multistep hierarchical assembly, and unique biomechanical functions.
Here we show that syntenin has a tightly regulated developmental profile in neurons and is most abundant in the period of intense growth and synapse formation and stabilization.
Differently from PrPC, Dpl is not physiologically detectable in the adult mouse brain, and the level of Dpl messenger RNA in the CNS is under strictly regulated developmental control [33].
Recently researchers have discovered that random fluctuations in gene expression caused by a mutation in a tightly regulated developmental pathway can also lead to incomplete penetrance by upsetting stable and buffered gene expression in a wild type background [44].
Asexual stage Plasmodium falciparum replicates and undergoes a tightly regulated developmental process in human erythrocytes.
Regulation of meiosis and sporulation in Saccharomyces cerevisiae is a model for a highly regulated developmental process.
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In contrast to Spred1 and Spred2, which regulate developmental lymphangiogenesis, Sprouty2 and Sprouty4 are important negative regulators of developmental angiogenesis in vivo.
In addition to regulating developmental angiogenesis, Eph receptors and ephrins have also emerged as critical regulators of tumor angiogenesis.
Specificity and precision of expression are essential for the genes that regulate developmental processes.
This phenotypic plasticity is obtained by integrating external signals with internal, mainly hormonal, signals that regulate developmental alterations.
N6-methyladenosine (m6A) affects multiple aspects of mRNA metabolism and regulates developmental transitions by promoting mRNA decay.
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