Even when involving students in experiments and letting professionals guarantee a more efficient and self-regulated detection of mistakes in the design of synthetic constructs, synthetic biology lacks an open process for setting priorities for its designs.
6, according to the procedures detailed the EU legislation regulating the detection of marine toxins in seafood (Decision 2002/225/EC).
PARE data suggest that speed for dicing at the steps during phased processing might be regulated, provided that detection of more intermediate products can serve as the signal for higher dicing speed for the corresponding step of slicing.
Our findings indicate instead that porphyrin metabolism, particularly in preadolescent children, may be too disordered or differently regulated to permit detection of the Hg-mediated changes in urinary porphyrin excretion apparent in adult subjects.
It remains to be seen how the techniques used for normalization or variance-stabilizing transforms will impact the accuracy and precision of regulated gene detection.
In addition, 11 riboswitches, which regulate translation through the detection of small molecules [ 26], were detected near the 5' ends of genes they presumably regulate.
DOI: http://dx.doi.org/10.7554/eLife.00290.011 10.7554/eLiFigure90.012 Figure 4 figure supplement 1. Kif2a is regulated by importin immunofluorescence detection of recombinant MBP or MBP fused to the motor domain of kif2a added at 250 nM to interphase egg extracts, showing kif2a nuclear import that is lost upon mutation of the NLS.
Opn4 has been shown to confer intrinsic photosensitivity on nonretinal cells [ 35, 36] and to be responsible for light detection, regulating a number of nonvisual activities (synchronization of biological rhythms, suppression of pineal melatonin, sleep, etc) in mammals [ 37] and nonmammalian vertebrates [ 1].
In addition to cell cycle progression and cell survival, TS regulate the detection and repair of DNA damage, protein turnover, autophagy, and metabolism.
It is conceivable that the neural substrates that regulate automatic monitoring and detection of environmental changes trigger a cascade of higher-order processing.
Lowering thresholds for the detection of significantly regulated genes using standard analysis approaches results in an increase in "background noise" in the experiment and increasingly unreliable results [15].
