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The interaction between Get3 and a TA protein substrate may thus represent a critical and potentially regulated decision step for establishing the destination target of TA proteins.
Population genetic data show that selfing is the primary mode of C. elegans reproduction; however, studies have identified significant rates of outcrossing in natural populations (Barriere et al. 2005; Sivasundar and Hey 2005), suggesting that hermaphrodite reproduction could be a naturally variable, regulated decision.
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Our model therefore includes a regulated decision-making process, called Checkpoint, which controls execution of one of the following options: (1) degrade (which includes decapping as a first subprocess), (2) store (sequestrate), and (3) unload (a condition for the P body-Ribosome Transport process, which releases mRNA back to the Ribosome).
Regulated splicing decisions largely depend on nucleotide sequences located in alternate exons or in neighboring introns that recruit specific splicing factors [ 1– 7].
down-regulated regulated.
The ultimate regulated variable is a decision or action (also see Kurth-Nelson and Redish, 2009).
Regulator-regulated gene associations.
Water management decisions in regulated rivers are associated with uncertainty and complexity.
Much of the research that the U.S. EPA relies on in making decisions regarding regulated chemicals, particularly pesticides, is not federally funded, although published studies cited in the U.S. EPA's Integrated Risk Information System (IRIS) often received federal funding.
Since this price enters the investment decision process of regulated firms, this uncertainty increases the cost of capital for investors and might deter investments into new technologies at the company level.
Hohn's counsel, Lewis Marks QC, said: "The husband was the sole decision-maker in this enterprise, makes all the investment decisions and is the regulated person as far as the Financial Services Authority is concerned.
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