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With default settings of a minimum of 3 probes matching to a de novo annotated transcript, 6,533 transcripts were found to be significantly regulated, corresponding to 2,626 genes.
In other words, our results suggest that a ROS-detoxifying system can be regulated corresponding to the intracellular level of oxidatively damaged DNA or the absence of DNA repair enzymes.
Other adipokines visfatin and apelin are also regulated corresponding to n-3 PUFA treatment without alteration in circulating levels, suggesting that both of them are incompetent to mediate systemic influence [ 101].
44 proteins were also dysregulated at the mRNA level (29 upregulated and 15 down regulated, corresponding to 50 DE probesets).
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In fact, 92% of probes mapped to EMT UP gene set (genes that were up-regulated in mesenchymal vs. epithelial lung cell lines) were positively correlated with PC1 and 82% of probes from EMT DOWN gene set (genes that were respectively down-regulated), corresponding to Fisher exact test p-value of 2 × 10-16 [ 18].
This is not consistent with the results for C. beijerinckii 8052 obtained in this study, where in both reactors the expression of spo0H tended to decline slightly corresponding to the initiation of solvent production, while spo0A was up-regulated corresponding to the solvent production and down-regulated before entering the stationary phase.
Using the TOM2 microarray, we identified 1016 diurnally regulated genes, corresponding to about 15% of the spots that passed quality controls.
Analysis of the resulting microarray data revealed a total of 1 486 significantly regulated genes, corresponding to 22% of the analyzable orfs included on the chip.
Our results suggested that DNA hypomethylation and hypermethylation may regulate corresponding genes involved in different processes.
We also measured gene expression and found SMGs were enriched in differentially expressed genes, implying that the accumulation of genetic aberrations may regulate corresponding gene expression and further affect tumor evolution.
We thus propose that the crosstalk motifs may play significant roles in PINs, which may have important downstream effects on several biological processes in living cells via regulating corresponding PPIs.
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