Sentence examples for regulated cleavage of from inspiring English sources

Induced shedding could be inhibited by BB-94, suggesting a metalloprotease involvement also in the regulated cleavage of CA IX ECD.

A critical requirement of the metaphase to anaphase transition is the regulated cleavage of the remaining centromeric cohesion prior to chromosome segregation.

If the mechanism through which ceramide regulates cleavage of CREB3L1 is similar to that employed by cholesterol to regulate cleavage of SREBP-2, then excessive ceramide is predicted to trigger the transportation of CREB3L1 from the ER to Golgi complex.

To assess if BAX has a role in 3NP-induced apoptosis partially through lysosomes by regulating cleavage of BID, BAX siRNA was infected into A549 cells and the effects of BAX siRNA on 3NP-induced cleavage of BID was examined.

SCAP (↓45d MN, ↓5d, ↓45d glia, MN+glia) is a regulatory protein that regulates cleavage of the sterol regulatory element-binding protein (SREBP) to maintain fatty acid homeostasis (Seegmiller et al. 2002).

In our study, oridonin treatment activated caspase-3 and caspase-9, regulated the cleavage of PARP-1.

Binding to membranes is regulated by cleavage of Bid to truncated Bid (tBid), by conformation changes in tBid and Bax, and by interactions with other proteins.

Thus far, no α-integrin-subunit-specific activating antibodies have been reported; however, an antimetastatic α6 integrin antibody that inhibits regulated ectodomain cleavage of the α6 subunit (but not α6-dependent adhesion) has recently been described (Ref. 44).

Given that miRNAs regulate the cleavage of targeted mRNAs, we focused on negatively regulated hyperoxia-responsive genes to identify potential targets of miRNAs.

MMPs and their inhibitors (tissue inhibitors of matrix metalloproteinases, TIMPs) contribute to the pathogenesis of asthma by regulating the cleavage of peptidic mediators that influence the functions and the migration of inflammatory cells and by modifying the extracellular matrix homeostasis.

In contrast to these substrates, the sheddase activity regulating the cleavage of IL-6R is in the early stages of being understood.