Sentence examples for regulated changes in from inspiring English sources

Therefore, CoMRe was designed to evaluate how co-variability of genome-wide gene pairs was dependent on modulator genes based on a multiple regression model; the analysis was focused on modulation, rather than direct or causal regulation, or co-regulation (i.e., regulated changes in gene expression levels).

Because MOP1 is known to be an epigenetic regulator of genes that demonstrate changes in nucleosome distribution during regulated changes in gene expression, nucleosome distribution may be misregulated in mop1 1 mutants due to the disruption of a MOP1-mediated chromatin-remodeling event at the TSSs of Yab15 and Lg1.

The MotifADE method [ 5] assumes that if up-regulated or down-regulated genes which contain certain transcriptional factor binding sites are co-ordinately regulated, changes in their expression levels could be explained by those transcriptional factors.

As in the cytoplasm, nuclear actin undergoes regulated changes in its polymerization state and these changes have been linked to chromosome dynamics and, more recently, to DNA repair.

Little is known about the molecular mechanisms governing developmentally regulated changes in gene expression and neuronal function during the maturation of human prefrontal cortex (PFC), including alterations in neuropsychiatric disease.

Linkage of Dsh to the β-catenin pathway involves regulated changes in Dsh stability, phosphorylation, and protein interactions [18] [20].

To determine if PTBP1 mediates sterol-regulated changes in alternative splicing, HepG2 cells were incubated with either a siRNA specific for PTBP1 or a non-targeting negative control for 18 hours, after which either 2.0 µM simvastatin or placebo was added for an additional 6 hours (n = 9).

By and large, these controls are thought to involve lineage- and developmentally-regulated changes in chromatin structure that precisely modulate the accessibility of individual Ig/TCR gene loci and/or segments, with their associated RSSs, to the unique RAG1/2 recombinase [3], [5], [10].

Given the strong evidence for sterol regulation of HMGCR splice variants, we tested whether there are also sterol-regulated changes in the relative amounts of alternatively spliced to full-length transcripts of other key regulatory genes involved in cholesterol metabolism - LDLR, HMGCS1, MVK, and PCSK9.

It is interesting that there is evidence of transcriptional regulation of starch in both Arabidopsis leaves where light- and sugar-regulated changes in starch occur over a 24-hr period, and in apple fruit where developmental regulation of starch takes place over a 146-day period.

The up-regulated or down-regulated changes in gene expression following GANT61 treatment and determined by cDNA microarray profiling, were confirmed by qRT-PCR (Figure 5).