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HDL is also a major carrier of tocopherol in the plasma and contributes to its regulated cellular uptake possibly via the cubilin/megalin receptor system [ 24].
Sun, J. et al. Tunable rigidity of (polymeric core - lipid shell) nanoparticore - lipidulated cellular uptake.
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HO is involved in regulating cellular uptake and storage of iron.
These membrane influx transporters are present in BBB to regulate cellular uptake of a number of endogenous compounds and clinically important drugs [ 97].
For example, the protein corona is reported to influence cellular uptake and inflammation32.
Escherichia coli NikR regulates cellular nickel uptake by binding to the nik operon in the presence of nickel and blocking transcription of genes encoding the nickel uptake transporter.
In the heart, contraction regulates cellular LCFA uptake through translocation of CD36 and possibly of other LCFA transporters from intracellular storage compartments to the sarcolemma.
IGF-II is a potent mitogen that induces cell proliferation and survival signals through activation of the IGF-I and Insulin receptors (IGF-IR, IR) while IGF-II circulating levels are regulated by cellular uptake through the IGF2 receptor.
Ritz, S. et al. Protein corona of nanoparticles: distinct proteins regulate the cellular uptake.
We report that the low density lipoprotein receptor (LDLR) regulates the cellular uptake and central nervous system levels of astrocyte-derived apoE.
Among other roles, it regulates glucose cellular uptake in mammals, recruiting GLUT4 transporters to the cell surface [ 41].
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