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The mechanism by which ERK1/2 regulated cell proliferation involved transcriptional regulation of genes necessary for cell cycle, including CyclinA, CyclinB, CyclinD1, CyclinE and c-Myc.
Apparently, G-CSF activated certain signaling pathways that negatively regulated cell proliferation or induced differentiation.
EMMPRIN also regulated cell proliferation in a VEGFR-2 dependant manner.
In addition to genes directly involved in cell cycle progression, genes that regulated cell proliferation were also altered in expression.
In the present study, extracellular Ca2+ and the calcimimetic NPS R-467 regulated cell proliferation with strong stimulation in the case of strongly lowered CaSR relative expression (as observed in the large cell line) but weak stimulation in the case of weakly lowered relative CaSR abundance (as observed in the small cell line).
It has been shown that the maintaining of HNE levels at 1 μM through repetitive treatments regulated cell proliferation and differentiation [ 32].
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This work provides support for the role of CD81 in the regulation of astrocyte and microglial number, perhaps by regulating cell proliferation by a contact inhibition-dependent mechanism.
Egr1 can act as a transcriptional regulator, with target genes including TGF-β, p53 and PTEN, thereby regulating cell proliferation and survival signaling in response to stress.
Ovca1 regulates cell proliferation, embryonic development, and tumorigenesis.
Chen, L. et al. Tripartite motif containing 28 (Trim28) can regulate cell proliferation by bridging HDAC1/E2F interactions.
The insulin receptor translocates to the nucleus to regulate cell proliferation in liver.
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