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Here, we demonstrate that activation of NMDAR bi-directionally regulated cell fate through stimulating pro-survival or pro-death signaling.
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Similarly, the mechanism by which stabilized p53 regulates cell fate, through transcriptional regulation of either cell cycle arrest or apoptotic targets, remains incomplete.
Regulation of protein protein interactions is one strategy to regulate cell fate in a highly selective manner.
Thus, in addition to regulation of other signalling pathways, β-catenin directly regulates cell fate specification of the midbrain dopaminergic neurons.
The Notch receptor family regulates cell fate through cell-cell communication.
Notch signaling pathway enhances neural stem cell characters and regulates cell fate decisions during neural development.
Mähönen, A. P. et al. Cytokinin signaling and its inhibitor AHP6 regulate cell fate during vascular development.
Stem or progenitor cell populations are often established in unique niche microenvironments that regulate cell fate decisions.
Fibroblast growth factor (FGF) signaling through its receptors, FGFR1, FGFR2, FGFR3, or FGFR4, regulates cell fate, angiogenesis, immunity, and metabolism.
Entropy increases due to a loss of the intra-tissue positional information that normally regulates cell fate and function.
Our lab uses high-resolution microscopy, genetics, and biochemistry to investigate how RNA granules assemble and how they regulate cell fate and function.
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