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These microarray data suggest that TPL2 expression in the prostate is inversely regulated by testosterone at the transcriptional level.
Indeed, Mup expression is regulated by testosterone, thyroxine, and growth hormone with adult males having much higher Mup levels in urine than females or juveniles [1], [2].
Cav-1 is regulated by testosterone, but at relatively modest levels when compared with PSA.
Previous studies on the rat model showed that Cx43 expression is directly regulated by testosterone in adult males [ 52].
In human cells, the researchers found that TCC increased gene expression that is normally regulated by testosterone.
Another reason for the ambiguous results of studies testing the immunosuppressive effect of T may be due to the diverse nature of sexual signals regulated by testosterone.
Similar(49)
ACTH release may be regulated by testosterone-dependent effects on AVP synthesis and by corticosterone-dependent effects on CRH synthesis in the PVN of the hypothalamus.
Although the microsomal fraction of this enzyme found throughout the epididymis appears to be regulated by circulating testosterone (18), 5α-reductase activity associated with the nuclear fraction is markedly and selectively down-regulated in IS after unilateral OE or EDL and cannot be maintained by exogenous testosterone (19, 20).
To elucidate signaling pathways regulated differentially by testosterone and rFst in prostate and muscle, we performed microarray analysis of mRNAs from prostate and levator ani of castrated male mice treated with vehicle, testosterone, or rFst.
Developments of HFs and AUs are regulated by similar endocrine (particularly testosterone) and paracrine (particularly IGF1) factors.
One isoform of these enzymes (GSTalpha) is shown to be active in the pig testis Leydig and Sertoli cells and positively regulated by both estradiol and testosterone [ 52].
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