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This indicates that CTPsyn is not the only protein to be regulated by spatial re-organisation in response to extrinsic signals.
Local stabilization of MTs, regulated by spatial cues provided from adhesion-mediated signaling, has been shown to lead to stabilizing ganglioside-containing plasma membrane rafts in fibroblasts (Palazzo et al., 2004).
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In fact, many important processes including cell-fate determination and embryonic development are regulated by spatial-temporal interactions of DNA, RNA, protein, and other small molecules [40].
In particular, distances between isolated genes and all others should be smaller than average distances between genes, as isolated genes tend to be co-regulated by spatial neighborhood via the 3D structure of the genome.
We find that 3D collective cancer invasion is regulated by the spatial heterogeneity, as well as the microscopic anisotropy of the ECM.
The average pH offset between the two instruments over the 22 d deployment period was 0.0042 ± 0.0126 (n = 883), with the precision primarily regulated by large spatial and temporal variability at the site.
In cells, enzymes of both classes are further regulated by their spatial context and kinases are often tethered to subcellular structures such as membranes or occur as parts of immobile scaffolding complexes.
The formation of the PE from the pericardial mesoderm is regulated by a delicate spatial distribution of members of the Bmp and Fgf growth factor family [9].
AAA+ proteases are frequently regulated by adaptors that modulate spatial and temporal control of protein turnover.
Taken together, these results suggest that organ identity and cell fate determination are highly regulated by the temporal and spatial expression of genes.
Both Ca2+ release and Ca2+ influx are regulated by cytosolic Ca2+; therefore, spatial segregation between IP3-Rs and STIM1-activated channels could be a mechanism for reducing interference between Ca2+ release and Ca2+ influx.
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