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More typically, the activity of OCS sensory domains is regulated by small molecule binding, for instance the PurR regulator acts as repressor of purine biosynthesis upon binding a purine co-repressor [ 4].
This is perhaps the first example of RNA binding protein regulation by a small molecule ligand, similar to the many examples of transcriptional regulators, such as the nuclear hormone receptors, that are regulated by small ligands.
COPI coat assembly is regulated by small GTPases of the Arf family and their regulator, the GTP exchange factor, GBF1; however, the regulation of COPI-coated carrier formation in response to extracellular signals is poorly understood.
These events are regulated by small Rab GTPases.
The functional activity of nuclear receptors is regulated by small molecular hormonal and synthetic molecules.
Such cavities are uncommon except in the case of ligand-binding proteins, leading to the hypothesis that HIF-2α can be regulated by small molecules.
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Our studies suggest that in addition to being regulated by small-scale oligomerization, allosteric control, competitive inhibition, and transcriptional and post-translational mechanisms, CtpS is also regulated by large-scale assembly into filaments comprising hundreds of subunits.
They can also either encode or be regulated by smaller ncRNAs, such as miRNAs.
These regions of the brain contain large neurons that are regulated by smaller inhibitory GABAergic or excitatory glutaminergic interneurons.
The second one is that the gene expression is regulated by multiple small effect eQTLs that are not detectable with a small population size.
At the time, Fannie and Freddie were regulated by a small agency within the Department of Housing and Urban Development; the bill proposed to create an independent agency to monitor their operations.
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