Sentence examples for regulated by polymorphisms from inspiring English sources

These studies suggest that serum concentrations of YKL-40 are, at least partly, regulated by polymorphisms in the proximal promotor region.

We also introduce the concept of transcriptional risk scores as a means of refining estimates of individual liability to disease based on targeted profiling of the transcripts that are regulated by polymorphisms jointly associated with disease and gene expression.

There is evidence that the level of activity of IL-6 and its receptor are regulated by functional polymorphisms in the corresponding genes [ 17].

Coding SNPs in this gene were previously shown to have no influence on mycobacterial infection [ 78, 80], but the degree of expression of this gene, possibly regulated by promoter polymorphisms, could determine the intensity of the cell-mediated immune response to mycobacteria [ 82].

Similarly, eQTL identified in an intercross of inbred C57BL/6J and DBA/2J mice could accurately identify transcripts in which expression was regulated by cis-acting polymorphisms [ 24].

Part of this differential NO expression is regulated by NOS3 promoter polymorphisms, specifically the -786T>C, which may have an influence on the progression of the disease and not on its occurrence.

Considering that cognitive impairment is involved in the development of dysfunctional (neural, synaptic) connectivity between brain regions [ 29, 30], the lower performance of working memory associated with the TT genotype in our patients may be ascribed to inefficiency in neural functioning, which is regulated by miR-137 polymorphism.

Similarly, IL-10 basal and induced production presented interindividual variations that were genetically regulated by three single nucleotide polymorphisms (SNPs) at positions -1,082(G/A), -819(C/T) and -592(C/A) of the IL-10 promoter.

We speculated that the expression of IL-4 polymorphisms maybe regulated by sex hormone.

It is likely that these polymorphisms can be transcriptionally regulated by Ahr, and, therefore, modulate various autoimmune diseases.

CYP1B1 activity is regulated by several functional non-synonymous single-nucleotide-polymorphisms (SNPs).