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One of the best known examples of such polymodal K2P channel regulation is the TREK-1 channel, which can be regulated by physical factors such as voltage, temperature and membrane stretch, as well as by a variety of chemical agents and natural ligands, including intracellular and extracellular protons, polyunsaturated fatty acids, phospholipids and volatile anaesthetics (Honore, 2007).
It was suggested that the release behaviors achieved by the dual-drug release system are regulated by physical properties, which is an important advantage for biomedical applications.
Storage and movement of water in and through each soil layer is regulated by physical properties that dictate moisture holding capacity, permanent wilting point moisture content, and infiltration rate.
Besides the canonical Hippo pathway, YAP/TAZ are also regulated by physical interactions with other proteins, especially cell junctional proteins.
An increasing number of experimental observations have demonstrated that tissue homeostasis could be strongly influenced and regulated by physical forces, such as the modulation of gravity vector.
FAP activity is regulated by physical and functional interactions with myofibers and SCs as well as cytokines released from innate immune cells.
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Neighborhood noise has become a serious problem in many countries, and it is difficult to regulate by physical means alone.
In animals, the transcription of time genes is regulated by a physical interaction of promoter-binding transcription regulators with cryptochromes; no such interaction has been found in plant-type cryptochromes.
The swelling process is regulated by many physical and chemical mechanisms, and can, to some extent, be fairly described by the poroelasticity theory.
Based on the types of gene expression regulation, promoters are divided into three categories: (i) constitutive promoters that are active constantly in most or all tissues; (ii) spatiotemporal promoters that have development-stage-specific or tissue-specific activity; and (iii) inducible promoters that are regulated by external physical or chemical signals (Ye et al. 2012).
Thus, knowledge of TFBS helps to identify potential target genes regulated by direct physical interaction with a transcription factor.
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