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EMD-induced VEGF production is regulated by pathways of an extracellular signal-regulated kinase inhibitor, p38 mitogen-activated protein kinase inhibitor, and phosphatidylinositol 3-kinase (PI3K /Akt inhibitor [ 33].
A third possibility is that DAF-16 activity may be regulated by pathways that function in parallel to AKT-1.
This reflects, in part, the fact that TFIIIB is strongly regulated by pathways involving oncogenes and tumor suppressors [ 4, 5].
The involvement of PPAR β in colorectal cancer is complex and seems to be regulated by pathways other than those controlling cellular differentiation.
Because their functions are regulated by pathways found to be dysregulated in cancer, certain FOXO proteins have been described as tumor suppressors [ 36– 40].
Ras is localized to the inner face of the plasma membrane and functions as a molecular switch that transmits receptor signals, but it can also be regulated by pathways dependent on Ca2+ influx, including at least one calmodulin-dependent pathway.
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We surmise that the recruitment of Wdr8 to the mitotic centrosome also is regulated by pathway(s) independent of hMsd1/SSX2IP.
This pathway is responsible for bone resorption and is mainly regulated by signaling pathways activated by RANK and immune receptors.
Thus, class I transcription is regulated by distinct pathways that converge on the core promoter.
By examining RNA levels, genes regulated by signaling pathways involved in inflammation and immunity were among the most enriched.
A number of genes showed highly correlated expression patterns suggesting that they may be regulated by similar pathways.
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