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Our observation that the expression of Gli2 by tumor cells is regulated by matrix rigidity is consistent with previous studies suggesting that Hh genes are regulated during development by mechanically transduced signals [43], [44].
Nonetheless, integrin signaling is regulated by matrix stiffness.
Tendon integrity depends on the extracellular matrix (ECM), which is regulated by matrix metalloproteinases (MMP).
Turnover of matrix proteins are regulated by matrix metalloproteinases (MMPs) [ 6].
This process is regulated by matrix metalloproteinases (MMPs) and their inhibitor enzymes, the tissue inhibitors of metalloproteinases (TIMPs).
Biomechanical sensing is regulated by matrix binding integrins and glycans that form the matrix glycocalyx, and thus offer a potential means to reduce flow responsiveness in cancer cells.
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ECM degradation, which is possibly regulated by matrix-degrading metalloproteinases (MMPs) and their endogenous tissue inhibitors, is closely involved in the outbreak of atherogenesis [ 19- 21].
Invadosomes are regulated by extracellular matrix signals and are endowed with degradative machinery for extracellular matrix.
Natural enamel has a hierarchically nanoassembled architecture that is regulated by enamel matrix proteins (EMPs) during the formation of enamel crystals.
The later stages are positively regulated by bone matrix proteins (BMP), which are members of the TGF-β superfamily [ 25].
The turnover of collagens is regulated by proteolytic matrix metalloproteinase (MMP) activity and their endogenous tissue inhibitors (TIMPs).
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