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This process could be regulated by excessive membrane phospholipid production [ 46], and it might be relevant that B. massiliensis retains several enzymes of phospholipid biosynthesis.
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Closer ER mitochondria juxtaposition (regulated by PSEN2) may expose mitochondria to excessive Ca2+ stimulation, triggering the apoptotic cascade by mitochondria Ca2+ overload.
This process is regulated by a negative feedback mechanism to prevent excessive acid secretion.
Partial hepatectomy triggers hepatocyte proliferation whereas excessive liver mass is regulated by apoptosis [ 7].
The concentration of extracellular nucleotides in the blood is tightly regulated by ectonucleotidases on leukocyte and endothelial cells to prevent excessive ADP accumulation and subsequent platelet activation [26].
Ero1 is tightly regulated by the formation of non-catalytic disulfides to prevent excessive hydrogen peroxide production.
In addition, the TLR-signalling pathways are strictly and finely regulated by positive or negative modulation at multiple levels to prevent excessive inflammation and achieve a balanced output [ 2, 4, 5].
Excessive intracellular copper has been found to be regulated by two proteins, ATP7A [70] and ATP7B [71].
A likely consequence of this situation is that many cellular processes can be coordinately regulated by stresses that affect the G- to F-actin ratio; some processes may be sensitive to excessive actin monomer or excessive actin filaments, while others may be sensitive to limitations in actin monomer or actin filaments.
Toll-like receptor 4 regulates intestinal homeostasis by preventing excessive inflammatory responses to commensal bacteria and could be regulated by histone deacetylation.
The growth retardation mediated by Os-PHR2 may be caused by toxicity of excessive Pi accumulation in shoots, or by some unknown genetic factor(s) regulated by Os-PHR2 (Wu and Xu, 2010).
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