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There was a significant change in some of the genes normally regulated by elevated levels of bile acids.
Retinoblastoma protein (pRb) whose activity is regulated by elevated p21 plays a crucial role for establishing the growth arrest.
For example, STS activity is higher in leukocytes in the third trimester of human pregnancy compared to nonpregnant females and adult males (48), an effect possibly regulated by elevated FSH concentrations (49).
Together these data support the hypothesis that most of the biochemical steps leading to the synthesis and secretion of proteins by FSH are regulated by elevated levels of cAMP.
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Its expression is regulated by an elevated concentration of the cell-internal amino acid, which may, for example, be the case in the presence of peptides.
CCM operation in algae is regulated by environmental factors with elevated CO2 levels expected to reduce the cellular requirements for concentrating Ci, and enabling enhanced growth [52].
A number of genes reportedly regulated by DNA methylation show elevated expression levels in Mbd3 −/− ES cells (Fig. 1A,B) (Reynolds et al., 2011).
We also examined the mRNA levels of the CDK inhibitors p21, p16, and p19, which are regulated by Bmi-1, and observed elevated levels of these transcripts in Atm-/ NSCs.
Moreover, genes regulated by JIL-1 kinase exhibit elevated levels of EB (Regnard et al. 2011) and EN (JIL-1 releases the paused RNA polymerase II at the proximal-promoter (Kellner et al. 2012), favoring transcriptional elongation bursts that increase EN [ Becskei et al. 2005; Kaern et al. 2005; Rajala et al. 2010]).
Also, AtMTP1 and BjMTP1 transcription is not regulated by Zn, while AtMTP3 is activated by elevated Zn influx [ 41, 43, 47].
In several in vitro studies, Serpine1 has been shown to regulate, and to be regulated by TGF-β1, and thus its elevated expression in our study may be a further indicator of increased TGF-β1 expression.
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