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Moreover, expression of genes for matrix metalloproteases, that are involved in tissue destruction and remodeling (MMP9, MMP12 and MMP14) and are regulated by chronic inflammation, were downregulated, while the negative regulator (TIMP1) of these proteases was upregulated in the lungs of CDC1551-infected ratbits allall time points [ 15].
Previous work showed modest induction of MBF-dependent transcripts 60 minutes after irradiation with 500 grays, suggesting that MBF may be regulated by chronic activation of the G2 DNA checkpoint [19].
Interestingly, other members of the PLP family such as M6b and DM20, but not PLP, are also regulated by chronic stress, and were shown to be involved in neurite outgrowth and filopodium formation [11].
We described four groups of genes regulated by chronic morphine treatment in zebrafish embryos.
We also analyzed four genes regulated by chronic morphine treatment involved specifically in dopaminergic and serotonergic neurotransmission.
Progression of chronic kidney disease is known to be regulated by chronic inflammatory and fibrotic process in the tubulointerstitium of the kidney.
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Potential factors regulated by fetal chronic hypoxia in maternal diabetes include VEGF, PlGF, FGF2, EPO, ANG2, and leptin.
Schmid et al. (18) found that CTRP-3 is positively regulated by insulin, whereas chronic LPS exposure inhibits CTRP-3 expression.
It has also been shown that nitrated α-syn inhibits Treg suppressive function, which implies that during PD the immune response to α-syn may not be tightly regulated by Treg and a chronic activation of the immune system can take place.
Finally, the mobility of α7-nAChRs was regulated by global network activity, with chronic application of TTX resulting in increased mobility and reduced cell surface expression.
Methylation of CDH1 has been reported to be regulated by H. pylori infection in chronic gastritis and intestinal metaplasia patients, indicating that E-cadherin plays an important role in gastric cancer initiation [ 60, 62].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com