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We then focus on how these stem cells are regulated by bone morphogenetic protein (BMP) and/or Wnt signaling by examining the interplays between these pathways.
To investigate the possibility that morphogenetic signals such as BMPs may regulate chondrocyte phenotype by modulation of cytoskeletal protein expression, we determined whether the expression and distribution of cytoskeletal proteins in chondrocytes are regulated by bone morphogenetic protein 7 (BMP 7), interleukin 1 (IL-1), and cellular context.
The latter is mainly regulated by bone morphogenetic protein (BMP), TGFβ and mesenchymal status (EMT) that are essential area of medical research [25].
Arl6ip5 is an ER-resident protein and regulated by bone metabolism factors in osteoblast.
Maintenance and mobilization of hematopoietic cells are regulated by bone cells.
The later stages are positively regulated by bone matrix proteins (BMP), which are members of the TGF-β superfamily [ 25].
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Bone mass is regulated by continuous bone remodeling through bone resorption and bone formation by osteoclasts and osteoblasts, respectively [ 3, 4].
These cells not only produce new bone but are also regulated by the bone matrix.
The density of bone is tightly regulated by the bone-forming osteoblasts and the bone-resorbing osteoclasts.
Stegner, D. et al. Thrombopoiesis is spatially regulated by the bone marrow vasculature.
There were a number of other matrix genes regulated by OP-1: bone sialoprotein, osteonectin, cadherins, chondroitin sulfate PG4 and dermatan sulfate PG3 (Table 9).
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