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Firstly, it was found that while a regulator could regulate more than one hundred targets, a gene was regulated by at the most six regulators.
TIA biosynthesis in C. roseus is a complex, multi-step process that is regulated by at least twelve transcriptional regulators.
Between the two GOFs, 86 genes were co-regulated (32 upregulated and 54 downregulated) from the total of 626 genes regulated by at least one GOF.
The general gene expression could be regulated by at least three aspects by DNA methylation.
(a) Schematic of the EGR1 promoter, whose activity is regulated by at least five serum-response element (SRE) consensus sites.
Four WRKYs were commonly regulated by at least 2 of 3 types of pathogens: WRKY40, WRKY75, WRKY33, WRKY35 and WRKY70 (Supplementary Table 2).
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The results show that the proposed RS score is highly correlated to the likelihood of a gene pair to be co-regulated by at least one common TF.
Of these, 17 genes were up-regulated by at-least 2.5 folds in the data we analyzed.
They were strongly up-regulated by at least two compounds, with some members affected by 3 compounds.
The analysis of the microarray data revealed that approximately 4.5% of the A. gambiae ESTs were up or down-regulated by at least 1.5-fold.
CCL18+TGFBI represents a good discriminator for kidney, pancreatic and stomach cancer, which are up-regulated by at least 2-fold in cancer tissues.
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