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This alignment is regulated by Vegfc/Vegfr3 signaling.
Blocking antibodies revealed that cell differentiation was regulated by integrin binding [ 283] in alignment with observations of preferential focal adhesions formation on –OH > –NH2 = –COOH > –CH3 surfaces [ 282].
10.7554/eLife.00290.011 Figure 4. Kif2a is regulated by importin α. (A ) Sequence alignment of region surrounding the nuclear localization signal (NLS) identified using PredictNLS program.
We have further proven this point by mapping orthologous gene pairs regulated by bidirectional promoters in twelve species using rigorous genomic alignment information [ 9].
CLUSTALW2 was used for sequence alignments of amastin, GT and 3'NT/Nase genes differentially regulated by the effect of pH and/or temperature and CBS's TMHMM 2.0 for the prediction of transmembrane helices in these proteins.
This alignment is essential for reliable synaptic transmission [33] and can be regulated by diverse signaling pathways [40], [41], [42].
However combining the networks generated by sequence alignment of expressed miRNAs and Targetscan, we predict that HNF4A is indirectly regulated by the let-7 family of miRNAs.
The PG also shows that the cell cycle is regulated by polarity-related checkpoints for septin ring organization (node 45860), spindle assembly (node 42254) and spindle alignment (node 6261).
At the same time, we found that MSNFs with alignment of the silica-nanochannels, a circular lamellar cylinder and other complicated mesostructures could be regulated by controlling the concentration of P123 in the precursor solution.
The observation of glucocorticoid regulation strongly associated with development-related pathways is in alignment with this model of GR signalling, and how multiple tissue and time-dependent events can be regulated by GR [ 52, 53].
Regulated by whom?
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