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The biogenesis and function of miRNAs are tightly regulated at several levels to ensure that proper regulation of the mRNA targets is maintained and adjusted in changing environmental conditions that includes posttranscriptional feedback regulation of DCL1 and AGO1 mRNA levels [ 16].
Taken together, these results indicate that CCR1-mediated responses are regulated at several steps in the signaling pathway, by receptor phosphorylation at the level of receptor/G protein coupling and by an unknown mechanism at the level of phospholipase C activation.
NF-κB activity can be regulated at several levels, including through alterations in cytoplasmic-nuclear shuttling.
The production of IL-1β is tightly regulated at several levels by "roadblocks" as defined by Dinarello [29].
MMP function is regulated at several levels.
This is likely regulated at several levels.
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EGR-1 regulates at least several genes involved in proliferation and inflammation, including TNF-α, PGE2 synthase and cyclin D1, supporting a role for the EP4 receptor in neoplastic processes [ 88].
It seems certain that, in addition to miRNA regulation, the production and secretion of hPGRN is regulated at multiple levels by several other mechanisms.
In contrast, the beam power for the TEF-P is regulated at a level of several watts to ensure the safety of the subcritical assembly.
It has become increasingly evident that in addition to gene regulation by TF binding to regulatory sequences, eukaryotic gene expression is also regulated at a higher level, and several studies have demonstrated the dependency of gene expression on the location of the gene within the genome [ 5- 7].
Cellulase production in filamentous fungi is largely regulated at the transcriptional level, and several transcription factors have been reported to be involved in this process.
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