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Analyses were performed on the genes regulated at one hour of hypoxia (H1), three hours of hypoxia (H3) and one hour of re-oxygenation (R1) since the largest numbers of genes were regulated at these times in all brain regions.
We found that a total of 376 reporters, 3.1% of all significant signals in gill, were significantly regulated at one or more time points.
Quantum identified 549 differentially regulated genes, 197 of which were also identified as being differentially regulated at one or more points in the DGAT 17 time series analysis.
The closest human orthologue to each of the genes designated as significantly regulated at one or more time points were imported into the software.
These results are consistent with the microarray data, where these genes were significantly down regulated at one dpi but not at two dpi (Additional file 1: Table S1 and Additional file 2: Table S2 respectively).
Genes that are up- or down regulated at one dpi, in response to full-length AC2 (FL) or a deletion derivative lacking the transcription activation domain (DEL), are shown.
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Nevertheless, it was seen that 325 were up-regulated and 60 genes were down-regulated, in response to Xoo infection in both the resistant and susceptible cultivars, excluding genes up-regulated at one time and down-regulated at another time.
Twenty-two leukocyte genes were significantly regulated at at least one time point during the experimental period.
We found 2964 genes differentially regulated at least for one condition (samples H and CS samples) in either of genotypes.
Although gene expression can be regulated at multiple levels, one of the most important regulatory mechanisms is at the transcriptional level.
inflammatory reaction amplification, pathogen associated molecular pattern recognition, cell adhesion, apoptosis, signal transduction, and oxidative burst were significantly regulated at at least one time point during the 24-h experimental period which covered disease onset to approximate clinical recovery.
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