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Coelho, F. M. et al. The chemokine receptors CXCR1/CXCR2 modulate antigen-induced arthritis by regulating adhesion of neutrophils to the synovial microvasculature.
A recent study shows that Radil regulates adhesion of cultured cells on fibronectin by activating β1-integrin.
These results indicate that BST-2 regulates adhesion of breast cancer cells to CAFs and to ECM proteins.
This study provides an additional mechanistic insight into how FREM1 regulates adhesion of the developing epidermis and identifies a key interaction with the PDGFC growth factor.
These findings suggest that CD155 has a role in cell size and shape, perhaps by regulating adhesion of cells to their substrate.
This suggests that c-FOS regulates adhesion of OvCa cells not only to the mesothelium, but also to underlying stromal components, potentially by reduced integrin levels.
Syndecans cooperate with a number of integrins to regulate adhesion to a variety of ECM ligands and, surprisingly, the mechanisms are quite diverse.
For example, CCN1 and CCN2 regulate adhesion in several types of cells [ 30].
Shen and Falzon explored the mechanism by which PTHrP regulates adhesion by examining expression of the transmembrane cell adhesion receptors, integrins, which mediate cell matrix and cell cell adhesion (Hynes, 2002).
In addition to modulating integrin activation, cells regulate adhesion by controlling the availability of integrins at the cell surface and within adhesive structures.
SPARC has also been shown to regulate adhesion and spreading of various types of tumor cells [ 35- 38].
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