The solution for many small mammals is to temporarily lower their energy needs by regulating a strong suppression of their metabolic rate, causing Tb to fall, and enter either short-term daily torpor or long-term (days or even weeks) continuous hibernation [3 5].
Another paralog of the Xa3/Xa26 family, the MRKa, could not mediate resistance to Xoo when regulated by its native promoter, but MRKa could confer partial resistance to Xoo when regulated by a strong constitutive promoter [ 13].
But if we want people to trust government statistics – and that is really important in a democracy – we need to understand that the free movement of labour will only work to society's advantage when it is regulated by a strong and energetic state.
We consider a gene to be directly regulated if a strong binding interaction was observed in our previously-generated ChIP-seq data set.
Selective depletion of lining macrophages using the clodronate-suicide technique prior to induction of collagenase-induced OA strongly inhibited development of cartilage destruction and osteophyte formation, probably regulated by a strong decrease in metalloproteinase (MMP -3 and −9 expression [ 22].
Overall the effects of rosiglitazone on PPARα and PGC1α regulated genes indicate a strong down regulation of genes involved in Lipid Metabolism and Energy Production in the heart which might contribute to the observed pathological hypertrophy because such effects were not observed with pioglitazone.
Nevertheless, significant enrichment of this pathway with transcriptionally regulated genes makes a strong argument for intense regulation of the integrin pathway throughout the lactation cycle.
Interestingly, no matter whether a lipid species was up or down-regulated, a strong dose effect was observed (Figure 10A).
This research revealed that gold nanoparticles, which are considered highly biocompatible in nature, can be regulated to be a strong antimicrobial agent by fine-tuning their surface functionalization in a controllable manner [26].
Furthermore, as miR-30b/c and miR-221/222 are regulated by MET, a strong downregulation was observed of these miRNAs when Calu-1 and A549-MET overexpressing cells were treated with MET inhibitors SU11274.
For example, one strategy may be more effective than the others in a population in which density dependence is weak while another may be better suited for a population regulated by strong density dependence (e.g., compare Fig. 3, β < 2 to β > 2).
