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In contrast, genes encoding metabolic enzymes and proteins involved in protein folding that were up-regulated in PCF appeared to primarily use mRNA abundance to regulate their expression.
They are positive regulators, and they bind to the promoter regions of the downstream genes to regulate their expression.
OsMYB61 has been reported to directly bind to the promoters of CESA genes to regulate their expression and cellulose biosynthesis (Huang et al., 2015).
Increasing knowledge of genomes and the intricate mechanisms that regulate their expression has aroused considerable interest in molecules that target nucleic acids.
Alternatively, N-Myc could regulate their expression in NSC as well as in neuroblastoma.
We functionally grouped upregulated genes by the cell signaling pathways that regulate their expression (Fig. 8a).
In response to osteogenic induction conditions in culture, SCAP begin to down regulate their expression of CD24 while gaining expression of ALP (Figure 3B).
We detected 29 proteins whose genes lack either a classic or atypical PhoP box, suggesting that PhoP may regulate their expression indirectly.
Some promoter regions of proinflammatory cytokine genes such as Marco and Clec4e contain C/EBP binding sites, and both C/EBPβ and C/EBPε can bind and regulate their expression.
As RNase L is an endoribonuclease, if these mRNAs were direct targets of RNase L, RNase L should regulate their expression at post-transcriptional level and decrease their half life.
Although the expression pattern of NPAS2 in this in vitro system did not match with those of type II and type X collagens (Figure 4B), the siRNA-derived knockdown study indicated that NPAS2 appeared to regulate their expression (Figure 4D).
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