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Since 5HT-stimulation of cells leads to the phosphorylation of vimentin on the Serine56 residue which alters the filamentous structure of this cytoskeletal protein [17], [18], the reorganization of the vimentin network should regulate the translocation of proteins that utilize the vimentin network [18].
Indeed, a recent study suggests that eIF3F could act potentially as a JAMM-containing DUB to regulate the translocation of NICD to the nucleus in cultured mammalian cells (Moretti et al. 2010).
These observations suggest that CYLD colocalizes preferentially with acetylated MTs, and that the TPA-mediated increase of acetylated MTs in the perinuclear region might in fact regulate the translocation of CYLD to this area.
In transformed cells, Akt1 appears to stimulate translocation of GLUT1 to the plasma membrane [ 107, 108]; however, there is currently no indication of what signaling molecules regulate the translocation of GLUT1 to the baso-lateral surface of mammary epithelial cells and to the Golgi at secretory activation.
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Because the phosphatase calcineurin regulates the translocation of Drp1, we then asked whether chymotrypsin affects Drp1 translocation and mitochondrial fission via calcineurin-related mechanisms.
However, the mechanism by which ERK regulates the translocation machinery of GLUT4 is still not clear.
In this study, we demonstrated that ERK stimulated by AMPK-induced PLD1 activation regulates the translocation of GLUT4 in L6 GLUT4-myc myotube cells.
Further analysis identified the ERK-dependent phosphorylation of Ser551 as a key step regulating the translocation of Gab1.
Sucrose transporters (SUTs) play important roles in regulating the translocation of assimilates from source to sink tissues.
Furthermore, PARP regulates the translocation of AIF in cardiac myocytes subjected to oxidative stress (Chen et al., 2004).
At nuclear envelope breakdown, Cdk1 regulates the translocation of STIL from early mitotic centrosomes to the cytoplasm thus triggering cartwheel disassembly.
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