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MicroRNAs are small non-coding RNAs known to regulate the target transcripts by promoting mRNA degradation and suppressing translation [1], [2].
Other factors also regulate the target state, including longitudinal forces (Jackson et al. 2002).
For example, small amount of heat shock proteins can efficiently regulate the target genes.
As reported, LncRNA could regulate the target protein mainly by directing binding to the target protein.
These complexes recognize target genes via complementary base pairing and regulate the target genes' expression.
This complex is then translocated to the nucleus, where it can regulate the target gene expression [ 33, 34].
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Phosphorylation on residue Ser5 was proposed to regulate the targeting of L-plastin to the actin cytoskeleton [9], [33].
These results suggest that endogenous Mieap may regulate the targeting of mitochondria by lysosomes in response to various mitochondrial stresses.
Since gene regulation is combinatorial, involving many TFs regulating common subsets of genes, it is of interest to determine which TFs also regulate the targets of WT1.
For example, these miRNAs might regulate the targets in different tissues, in response to different pathogens or could act to generate tasiRNAs from these loci [ 48].
It is possible that PPARβ/δ regulates these genes in regions further away than ± 10 kb from the TSS, or that regulation is mediated by another direct PPARβ/δ target gene that in turn directly regulates the target genes.
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