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The exogenous glucocorticoids regulate the secretion of CRH from PVN via feedback regulation on hypothalamic-pituitary adrenal cortex axis (HPAA), reduce stress response, influence responses in hippocampus and other limbic system, and impact the arousal, cognition and affection [ 2, 3].
For example GABA is secreted from beta cells and activation of islet GABAB receptors can regulate the secretion of insulin [6].
The hypothalamic neurosecretory system is also involved in the function of the negative-feedback mechanisms that regulate the secretion of the tropic hormones.
The exact molecular mechanisms by which polyamines selectively regulate the secretion of serotonin from activated MCs remain to be elucidated.
The first wave comprises up- or downregulation of a number of signaling substances that, in turn, regulate the secretion of the aforementioned steroids.
p53 can regulate the secretion of cytochrome c to initiate the mitochondria-dependent pathway, leading to the activation of caspase-9 then caspase-3 followed by apoptosis [39].
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There are some indications that Rho GTPases could play a role in regulating the secretion and/or activation of secreted proteases.
Recent results have also highlighted specific functional roles for O-glycans; for instance, in regulating the secretion of the phosphatemia regulator FGF23 (Kato et al., 2006) and in processing of the angiopoietin-like factor ANGPTL2 (Schjoldager et al., 2010).
It also regulates the secretion of various hormones and aids in the functioning of various enzymes within the body.
Histamine has a physiological role in regulating the secretion of acid in the stomach, where it stimulates the parietal cells to produce hydrochloric acid.
Scientists believe they have found the "fountain of ageing" in the shape of the hypothalamus, a small region of the brain involved in regulating the secretion of various hormones.
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