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The next exciting realisation was that these genes that were associated with viruses and found to regulate the proliferative capacity of cells were not only regulating proliferative capacity but also many other cellular functions.
However, dendritic cells secrete cysteine and in this way regulate the proliferative potential of local T cells by controlling cysteine availability [17].
Thus, Wnt signaling through Lrp5 may regulate the proliferative potential of the basal mammary stem cell population by inhibiting senescence (as it does in various human cell lines in vitro, [69]).
These in vitro results support the in vivo anti-inflammatory role of PLC-β3 and SHP-1 that regulate the proliferative and chemotactic behavior of mast cells by controlling Stat5 activity.
In particular, Pbx and Meis proteins and Runx and CBFβ, are all known to regulate the proliferative potential of haematopoietic stem cells (Chen et al., 2009; Okuda et al., 1996; Thorsteinsdottir et al., 2001; Wang et al., 2006).
Furthermore, in the normal mammary gland, ER-positive cells are quiescent and act as "steroid hormone sensors," producing paracrine/juxtacrine factors to regulate the proliferative activity of adjacent ER-negative epithelial cells.
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Bmi-1, a polycomb group gene, regulates the proliferative activity of normal stem and progenitor cells [6].
P73 is involved in a variety of processes ranging from nervous system development to governing inflammation [5], [6] whereas p63 regulates the proliferative potential of the epidermis [7] [9].
We found that FABP7 regulated the proliferative response of astrocytes to injury.
We showed that ZEB1 is a key player in promoting the mesenchymal phenotype and regulating the proliferative rate in ET cells through the direct transcriptional repression of MYB.
We can hypothesise that the addition of sCTLA-4 to MLR test not only regulates the proliferative response, but also modulate cytokine production.
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