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The mechanisms that regulate the probability of OR gene choice remain unclear.
Furthermore, some transcription-repressive chromatin regulatory factors regulate the probability of inactivation of gene expression rather than suppressing gene expression levels in the cell population.
Thus, the P and H elements regulate the probability of OR gene choice, not OR transcript level per OSN.
In fact, splice variants of Cavβ have been found that lack the GK domain, yet are still able to regulate the probability of channel opening, Po [12], [13].
Thus, by varying the length of one unit while keeping the other constant, we can regulate the probability of the desired recombination, and control the sparseness level of gene activation.
To gain insight into how Syp may regulate the probability of vesicle secretion, we performed transmission electron microscopy on third instar larval junctions.
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Tsix-mediated repression in turn regulates the probability of a given Xist allele being expressed in XX heterozygotes [ 7- 11].
Collectively, our results support a novel model in which the same cargo species can interact with processive or non-processive dynein, with discrete cargo-associated features regulating the probability of switching between the two behaviours.
Maternal nutritional status regulates the probability of conception (Schneider 2004; Wade et al., 1996), whereas baseline adiposity and pregnancy weight gain contribute to growth of the fetus (Anderson et al., 1984).
We set the default value for the depth at 3. Threshold parameter θ: the threshold parameter θ is critical in our method because it regulates the probability of equiprobable oligomers p. Empirically, we can obtain good results when we set p=1/ L, where L is the total sum of the lengths of the input sequences.
The model whereby the presence of cell type-specific TFs is the central mechanism by which cell fate is determined, and chromatin structure simply regulates the probability that TFs bind their genomic targets, suggests that reprogramming to pluripotency can only be induced when the somatic nucleus is exposed to the pluripotent TFs (through ectopic iPSC factor expression, cell fusion, or SCNT).
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