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Overall, the hydrogel design strategy presented in this study will be highly useful to better regulate the phenotype and ultimately improve the therapeutic efficacy of a wide array of cells used in various biology studies and clinical settings.
We hypothesized that hydrogels presenting both the RGD peptide and the YIGSR peptide (Tyr-Ile-Gly-Ser-Arg) could successfully regulate the phenotype of PC12 cells, thereby providing a new platform for effective tissue engineering applications.
As the ratio between severe and mild cases was nearly 1∶1, such a single gene might regulate the phenotype diversity in gcm; hAtx1-82Q flies.
Multiple miRs can regulate the phenotype of tumor cells in these stages.
Hypoxia might be one of the key attributes in the tumor microenvironment that can regulate the phenotype of CSCs.
The emerging roles of CAFs in cancer immunoeditting led us to investigate whether GC-MSCs are able to regulate the phenotype and function of neutrophils in gastric cancer.
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IL-4 can directly regulate the phenotypes and effector function of tumor-associated CD11b+Gr-1-F4/80+ macrophages, wereh wereportedtod to promote the invasive and metastatic behavior of malignant mammary epithelial cells by secreting EGF and activating EGFR signaling programs in tumor epithelial cells (DeNardo et al., 2009).
Hence, the different profiles of 24-nt sRNAs may influence the expression of associated genes to regulate the phenotypes.
In contrast, Elongin-B, another ubiquitin-ligase core component, itself regulated the phenotype of the SAC, condensin/cohesin components and cytokinesis regulators.
The mechanical stiffness of a hydrogel plays a significant role in regulating the phenotype of cells that adhere to its surface.
This study examines the contributions of exogenous and endogenous hyaluronic acid (HA), in both two-dimensional (2-D) and 3-D environments, in regulating the phenotype and calcification of VICs.
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