Sentence examples for regulate the malignant from inspiring English sources

For example, matrix stiffness has been proposed to regulate the malignant phenotype of cancer cells [46], the geometric arrangement of cell contacts was shown to alter the response of skin cells to cytotoxic agents [47], and the susceptibility of cells to non-viral gene delivery depends upon the stiffness of 2-D culture substrates [48].

These data suggest that NS may regulate the malignant phenotypes, such as enhanced cell proliferation and invasion, in OSCC via the STAT3 signalling pathway.

Through adenovirus-mediated NDRG2 overexpression or siRNA-mediated NDRG2 down-regulation in HCC cell lines and immunohistochemistry of HCC clinical specimens, NDRG2 was found to regulate the malignant behaviors of HCC by altering the expression of CD24; moreover, our data suggest that NDRG2 may be a suitable diagnostic marker of HCC.

Additional studies are required to fully understand the mechanism by which Oct3/4 and Nanog regulate the malignant behaviors of CSCs, as well as to establish the optimal criteria for estimating the latent malignant potential of cancer at the early stage using CSC-related molecular markers.

One possible mechanism by which KCC regulates the malignant behavior of cancer cells may be through the regulation of [Cl−]i [ 11, 13].

Future investigations of the NB carcinogenesis process can address future therapies to re-regulate the malignant cell cycle.

Which β4GalNAcT is responsible for regulating the malignant properties of the tumors and cancer cells?

This indicates that miR-148a likely plays an important role in regulating the malignant progression of tumor cells.

MiRNAs are increasingly implicated in regulating the malignant progression of cancer by directly targeting oncogenes and tumor suppressor genes [ 29].

Thus, it is realistic to assume that TS might play an important role in regulating the malignant potential in many types of cancer not only in lung cancer.

TGF-β and PTHrP were confirmed to be involved in regulating the malignant progression in breast cancer, and PTHrP expression, to be associated with bone metastasis as a potential prognostic marker in ER negative breast cancer.