These analyses support a primary role for CTCF in the global organization of chromatin architecture and suggest that CTCF may be a heritable component of an epigenetic system regulating the interplay between DNA methylation, higher-order chromatin structure, and lineage-specific gene expression.
Recent evidence indicates that CTCF is involved in the global organization of chromatin, and "may be a heritable component of an epigenetic system regulating the interplay between DNA methylation, higher-order chromatin structure, and lineage-specific gene expression" [3].
NF-κB activity can be perturbed in a variety of non-parenchymal and parenchymal liver cells during hepatic inflammation, fibrosis and the development of hepatocellular carcinoma, and regulates the interplay between immune, fibrogenic and oncogenic mediators [ 17].
CD40 ligand (CD40L), or CD154, is expressed on activated T lymphocytes, and through interactions with its receptor CD40, plays a pivotal role in regulating the interplay between T cells and other cell types [ 1– 3].
This same cross talk between autophagy and apoptosis has also been shown for other chemotherapy agents, including temozolomide, arsenic trioxide, resveratrol, camptothecin, cisplatin and 5-fluoracil, in many types of tumor cells But still, the molecular mechanisms regulating the interplay between these two events are poorly understood.
Tendon development is regulated by the interplay between TGF-β, Wnt, and FGF signaling pathways.
Normal tissue development and function are regulated by the interplay between cells and their surrounding extracellular matrix (ECM).
Perhaps the final DNA methylation status is regulated by the interplay between methylase and demethylase genes.
As with BASE-C in solution, these pH and ionic strength dependencies suggest that peptide folding is regulated by the interplay between electrostatic and hydrophobic effects.
A similar mechanism has been postulated to account for the bistable R3/R4 fate determination in the Drosophila compound eye, which is regulated by the interplay between Wg/Wnt and N signaling (Cooper and Bray, 1999; Fanto and Mlodzik, 1999).
