Because the induction of conformational changes in the integrin receptors 49 regulate the exposure of the binding site, the ligand-binding domain of the activated integrin heterodimer needs to be located at a defined minimum distance.
The observed conformational differences may thus serve to regulate the exposure of the aromatic patch, and the conservation of the patch suggests that it is important, perhaps in interactions with regulatory ligands or with other regions of the full TRPV4 homotetramer.
Christian iconography has tended to be half in love with flesh as an object of mortification, as in the crucifixion of Christ, while the Judaic tradition strictly regulates the exposure of flesh for both men and women.
Given the central role of the PAZ motions in regulating the exposure of the nucleic acid binding channel, these findings exemplify the importance of protein motions in distinguishing the overlapping, yet distinct, mechanisms of Ago-mediated processes in different organisms.
Based on this last activity, the nucleolus can be regarded as a reservoir of regulatory proteins, acting as a sequestering compartment for regulatory complexes, or regulating the exposure of proteins to proteolysis during developmental decision-making (Hand 1) [38], hypoxia sensing responses (VHL) [39], cell death and proliferation (AKT, p53, ARF, MDM2, c-myc) and mitosis (Cdc14).
Further, molecular dynamics studies suggest that, in the presence of force, Ser2152 phosphorylation of filamin A Ig repeat 20 regulates the exposure of the cryptic integrin-binding site.
It was previously proposed that the function of the N-terminal portion of CSP is to mask the cell-adhesive TSR domain as sporozoites migrate through the skin and controlled proteolytic processing of CSP by a parasite protease regulates the exposure of the TSR (Coppi et al., 2005, 2011).
In a previous study, we found that nano-SiO2 exposure regulate the expression of the poly(ADP-ribose) polymerases-1 (PARP-1), a pivotal DNA repair gene, in human HaCaT cells.
In industrial settings, where benzene is used as a solvent and in chemical manufacturing, a higher risk of leukemia led the United States in 1987 to regulate the maximum allowable workplace exposure at 1 ppm of benzene averaged over 8 hours.
Although the extent of AgNP accumulation was not determined, the chorion may delay AgNP exposure to embryos, indicating that exposure characteristics regulate the time interval of toxicity occurrence between embryo and adult stages.
Comparison of the transcription factors associated with primary and PCA pollutant exposure revealed six common, overlapping transcription factors predicted to regulate the genomic responses to both exposure conditions.
