Sentence examples for regulate the epigenetic from inspiring English sources

Therefore, deciphering the pathways that regulate the epigenetic modulation of gene expression is a major milestone for the understanding of diverse biological mechanisms and subsequently human pathologies.

First, it may regulate the epigenetic state of chromatine, modulating the methylation state of DNA and/or histones [27], [43], [44].

There have been some reports suggesting that other signaling pathways regulate the epigenetic state.

It has been shown that miRNAs themselves can regulate the epigenetic machinery by directly targeting their enzymatic mediators such as DNMTs [ 123].

One interesting feature is that TALEs fused with histone-deacetylating epigenetic effectors could regulate the epigenetic status i n vivo[ 43, 44].

In Drosophila, PREs were shown to generate ncRNAs that regulate the epigenetic status of the locus (Bae et al., 2002; Lipshitz et al., 1987; Petruk et al., 2006; Rank et al., 2002; Sanchez-Elsner et al., 2006; Schmitt et al., 2005).

In addition the UPIC Os12g41900 gene, orthologous to AtSDG25 (SET DOMAIN GROUP25), regulates the epigenetic transcriptional activation and contributes to the regulation of FLC (FLOWERING LOCUS C), a gene involved in flowering induction in the shoot apical meristem [ 46, 47].

PRDM16 regulates the epigenetic state of transcriptional enhancers to activate genes involved in intermediate progenitor cell production and repress genes involved in cell migration.

The rising genes started to produce transcripts that acquired function in regulating the epigenetic status of the X chromosome, as shown for Xist, its antisense Tsix, Jpx, and recently suggested for Ftx.

Since identification of proteins arginylated in vivo is only at its initial stages, it is also possible that some of the arginylated proteins, or proteins regulated by arginyltransferase, have additional roles in germ cell development, for example in regulating the epigenetic modifications essential for normal gametogenesis.

Taken together, we hypothesize that MECOM/EVI1 regulates the epigenetic machinery enabling stem cell-like properties in specific melanoma subpopulations.