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Since functional AMPK is an obligate heterotrimer, reduced levels of one subunit has previously been shown to lead to the instability of the others [21], which is consistent with our results, and suggests complex feedback mechanisms to regulate the dosage of all subunits.
The major strength of this study is that it clarifies the effects of smoking on the olanzapine and clozapine concentrations in a large population and provides standards that can be used to regulate the dosage of olanzapine and clozapine in clinical practice based on the patient's smoking status.
These findings suggest that despite the various molecular changes that can take place in a miRNA-miRNA* duplex, the expression ratio at which these molecules are found expressed in distinct taxa remains unchanged reflecting that other mechanisms may regulate the dosage at which each molecule is present to properly control downstream targets.
The problem is that you can't regulate the dosage.
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Hydrophobic fluorinated polyurethanes (FPU) without hydrophilic CH2OH groups were prepared by introducing fluorine with the method of perfluoroalkyl ethanols (TEOH-10) for modification of diphenyl-methane-diisocyanates (MDI) and regulating the dosage and time of the MDI added.
36 Because the smokers who were treated with clozapine were reported to suffer from serious central nervous side effects after smoking cessation, 4 13–16 it is necessary to regulate the clozapine dosage carefully when smokers stop smoking or decrease the amount of smoking.
Sferios stresses that each of these patients were in care of therapists and trained prescribers who knew exactly how to regulate the drug's dosage.
Because gene loss on the degenerating Y chromosome can lead to reduced expression in males, the X often evolves mechanisms of dosage compensation, which regulate the expression of X-linked genes to compensate for their haploidy in males (Charlesworth 1998).
Regulate the soil temperature.
Regulate the room temperature.
SXL also regulates the process of dosage compensation, which is the mechanism that yields roughly the same amount of transcript from the single × chromosome in males to that of the two × chromosomes in females [reviewed in [ 20]].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com