Many studies have indicated that OsMADS45 interacts with other MADS proteins to co-regulate the determination of floral organ identities (Seok et al. 2010).
GLABROUS 1 (GL1), an important component of the trichome-promoting complex regulating the determination of trichome cell fate, however, was not identified in our dataset.
Moreover, it seems that these modules may have been co-opted during evolution to regulate the decision underlying cell-fate determination of different structures in diverse tissues/organs (e.g. root, hypocotyl and leaf).
This is consistent with the opposing activities of ash1 and Su z 12/ E z) and the idea that PcG/trxG proteins regulate the sex determination decision.
This is particularly intriguing and warrants future investigation into miR-133's functions in myogenesis and adipogenesis to elucidate how this single miRNA can regulate the cell fate determination and switching.
(51) GATA-3 regulates the lineage determination and differentiation of many cell types, 52) as well as playing a crucial role during mammary gland development.
FOXA1 and ERα have been explored as potential participants involved in mammary tumours together with another gene, GATA-3 [ 21, 22], which regulates the lineage determination and differentiation of many cells types.
In the embryonic pancreas, at least two atonal-related bHLH genes regulate the endocrine islet cell determination program: Neurog3 initiates endocrine differentiation and induces NeuroD1, which maintains endocrine differentiation [7][16].
For example, whether the p62 stability is regulated for the determination of its protein levels, and how is it connected with the balance between autophagy and proteasome pathway?
Our study not only established an ideal platform to investigate the transcriptional network regulating the RPE cell fate determination, but also provided an alternative strategy to generate functional RPE cells that complement the use of pluripotent stem cells for disease modeling, drug screening, and cell therapy of retinal degeneration.
