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These data demonstrate a new mode of regulation: Rab6A can regulate the binding of KIF1C to microtubules by direct interaction with the KIF1C motor domain.
We sought to specifically regulate the binding of human C1q, and thus the activation of the first complement component, via the construction of a single chain antibody variable binding region fragment (scFv) targeting the C1q globular heads.
Amino acids regulate the binding of nucleotides to RagA/B, such that amino acid stimulation increases their guanosine triphosphate (GTP) loading, which leads to the recruitment and binding of mTORC1.
Further study confirmed that H3S10 phosphorylation provides a binding platform for the phospho-binding 14-3-3 14-3-3 14-3-3histone acetyltransferase MOF to trigger acetylation of histone H4 at lysine 16 (H4K16ac), and H3S10 proteinsylandon and histone further coordinacetyltransferasethe binding site for broMOFomain protoin BRD4 (Zippo etrigger2009).
In addition, all three could conditionally regulate the binding of RelB binding with promoter DNA.
In addition, protein modification by phosphorylation represents a very rapid mechanism to regulate the binding capacity of tau.
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Together, these data further supports the idea that Spt16p may cooperate with Sir1p and function in regulating the binding of Sir2 4p binding to heterochromatic region.
The binding selectivity to F− over other anions may be greatly improved by down-regulating the binding constant to F− through structure optimization.
Further, the results obtained with monolayer film techniques demonstrate that the C-terminal region regulates the binding of PLA1 to PC.
In glycerol kinase, it is shown that the proposed domain motion prevents competition with water, in turn regulating the binding of glycerol.
In all the three receptors it was observed that the formation of 3a·Ag+/3b·Pb2+/3c·Cu2+ complex triggers the decomplexation of K+ ion from crown moiety and acts as a gateway, which regulates the binding of alkali metal to crown moiety.
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