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Based on these animal models, it has been proposed that G3 may regulate the attachment of GAG chains and affect the secretion of aggrecan.
In this work, a facile approach was proposed to construct surface nanostructure and metal ion incorporation for titanium foam to regulate the attachment and osteogenic differentiation of bone marrow derived mesenchymal stem cells (MSCs).
Vergeer speculates that the abnormal methylation might result from some of the rare genes exposed by inbreeding, especially if these genes help regulate the attachment and removal of methyl groups.
Chromosome behaviour in mitosis is directed by kinetochores, which regulate the attachment and movement of chromosomes on the mitotic spindle, and ensure the fidelity of chromosome segregation (Rieder and Maiato, 2004; Musacchio and Salmon, 2007).
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Furthermore, other data supports that Glc7 plays a key role in regulating the attachment of kinetochore microtubules to chromosomes.
These findings strongly suggest that rac1 functions in the same pathway as Ret and integrins in regulating the attachment of dendrites to the ECM.
Schoenwaelder, S.M. et al. Tyrosine kinases regulate the cytoskeletal attachment of integrin alpha IIb beta 3 (platelet glycoprotein IIb/IIIa) and the cellular retraction of fibrin polymers.
Using α2-knockout keratinocytes and dermal fibroblasts, it was shown that α2 integrin regulates the cell attachment and migration on collagen I, whereas adhesion to collagen IV and laminin I is permissive.
Centromere function ensures accurate chromosome segregation during mitosis and meiosis, as the centromere dictates assembly of the kinetochore that, in turn, regulates the spindle attachment checkpoint (SAC), which delays anaphase onset until all chromosomes are correctly attached in a bipolar fashion to the mitotic spindle.
Noticeably, however, in fission yeast, a well-studied model in mitosis research, it was unknown whether the single Aurora kinase, Ark1, has any role in regulating the proper attachment of chromosomes during mitosis.
By modulating the expression of miR-30 family we were able to regulate the growth in non-attachment conditions, as shown by sphere formation assays performed in vitro, and ex vivo.
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