Sentence examples for regulate the aberrant from inspiring English sources

These observations suggest that in addition to LOH, promoter methylation, and the APC mutations, miRNAs that target APC may regulate the aberrant activation of the canonical WNT signaling pathway for the initiation of human breast cancers, the enhancement of niche independence, and the aberrant proliferation of the human BCSCs.

These studies strongly suggested that MSK1 might contribute to tumor promoter-induced cell transformation and tumorigenic progression through regulating the aberrant expression of specific genes.

We applied our computational framework to the expression profiles of the miRNA/mRNA from Mir122a -/- mutant mice and wild-type mice and found a miRNA-mediated network involving 40 curated TFs regulating the aberrant expression of 65 miRNAs and 723 curated miRNA target genes, of which 56% was found in the differentially expressed genes of Mir122a -/- mice.

Breast cancer is a heterogenous disease whose progression from atypical ductal hyperplasia (ADH) to ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) is regulated by the aberrant expression of multiple mediators produced by the mammary tumor itself and the adjacent reactive stroma [ 1].

Emphasis is placed on the events that initiate and regulate the inflammatory response and diseases that result from aberrant regulation.

Emphasis is placed on the cells and events that initiate and regulate the inflammatory/immune response and diseases that result from aberrant regulation.

The authors conclude that cell-type-specific factors regulate the molecular architecture and distinctive harmful properties of aberrant α-synuclein aggregates.

Aberrant transcripts that fail to regulate the expression of mRNA are a cause of cancer development.

In sum, the promoter aberrant methylation patterns identified here likely regulate the transcriptome in SZ.

The DUSP genes regulate the activity of MAPK signaling cascades, and several map kinase targets are known to be involved in aberrant proliferation in cancer.

Regulate the soil temperature.