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Regulator molecules including growth factors and signaling molecules are major factors with the key ability to regulate stem cell behaviors, However, naturally occurring regulator molecules suffer from short circulation half-life and fast degradation rate under in vivo circumstances.
Signer, R. A. J. & Morrison, S. J. Mechanisms that regulate stem cell aging and life span.
BAM receptors regulate stem cell specification and organ development through complex interactions with CLAVATA signaling.
Reilly, G. C. & Engler, A. J. Intrinsic extracellular matrix properties regulate stem cell differentiation.
Chaudhuri, O. et al. Hydrogels with tunable stress relaxation regulate stem cell fate and activity.
SOX-2, a stem cell marker, has proven to regulate stem cell self-renewal and maintain its pluripotency40.
Here we show the existence of anisotropic inhibitory signal to regulate stem cell formation in the moss Physcomitrella patens.
We also discussed most recently magnificent materials and their effects to regulate stem cell fate.
"Hydrogels with tunable stress relaxation regulate stem cell fate and activity". Nature materials 15 (3): 326-334.
Indeed, in Drosophila melanogaster, crosstalk of hippo signalling with other pathways including Wnt, Tgfβ and Notch has been shown to regulate stem cell fate35.
Fujimaki, S. et al. Notch1 and Notch2 coordinately regulate stem cell function in the quiescent and activated states of muscle satellite cells.
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