A complex network of transcription factors regulates specification of the root stem cell niche.
As previously discussed, Met regulates specification, axonal growth, and survival of MN subtypes during development.
In addition to investigations of extracellular signals, numerous studies have focused on identifying the transcription factors that regulate oligodendrocyte specification and differentiation (for overviews, see Wegner, 2008; Li et al., 2009; Emery, 2010a, 2010b).
For example, TH appears to regulate fate specification of early cortical neurons [14], migration of cortical [15] and cerebellar [16] neurons, synaptogenesis[17], [18] and apoptosis [19], [20].
These two genetic backgrounds have been used extensively for elucidating the mechanisms that regulate the specification of an INP identity in the immature INP (Xiao et al., 2012; Janssens et al., 2014; Komori et al., 2014).
Notch signaling pathways regulate lineage specification decisions during development of numerous tissues [4].
A hierarchy of transcription factors regulate pancreatic specification, growth and differentiation.
The Wnt family of secreted glycoproteins, well characterized for their roles in several developmental processes including cell fate specification, axis patterning, and neural development (for reviews see [17] [19]), also regulate synapse development (for reviews see [20], [21]).
For instance, integrin-ECM binding regulates the specification of tip and stalk cells through modulation of Dll4/Notch signaling, thus controlling vessel sprouting.
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Park, H. C. & Appel, B. Delta-Notch signaling regulates oligodendrocyte specification.
