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The most commonly used drug delivery systems rely on diffusion to regulate release of target factors.
The same factors that regulate iron absorption also regulate release of storage iron from macrophages to the plasma to supply iron for erythropoiesis and other metabolic activities [3].
It is likely that there are additional hormonal signals or neuronal inputs that regulate release of DILPs from IPCs, as has been shown for pancreatic β-cells in mammals (see [20], [21], [22], [23]).
Overall, we predict that transport of APL-1 witheneuronnenablesnables APL-1 to properly perform its multiple functions by introducing the protein to molecules that can cleave and regulate release of the critically important N-terminal portion of the protein.
Furthermore the ceramide-dependent machinery has been reported to regulate release of miRNAs [ 69].
Modifications to synthetic hydrogels to promote integration, integrate bioactive signals, and regulate release of soluble factors are areas under investigation.
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3MH release, on the other hand, appears to be mediated by more than one gene (Roncoroni et al. 2011; Thibon et al. 2008), therefore it is reasonable to speculate that the treatments in our study have differentially regulated release of these thiols.
BTX-A injections are also known to be useful in treating chronic neuropathic pain, possibly with its analgesic effect that is suggested to employ independent action on peripheral nociceptors by regulating release of various endogenous chemicals such as glutamate, calcitonin gene-related peptide, and substance P [12].
α7-nAChRs are also located presynaptically, regulating release of various neurotransmitters [15], [16], [17], [18].
Pro- and anti-apoptotic Bcl-2 family proteins play an important role in regulating the intrinsic apoptotic pathway and in particular Bax, a principal effector pro-apoptotic Bcl-2 family member plays an important role in H/R induced apoptosis by regulating release of cytochrome c [34].
Results demonstrated that amylin was not only stored in gastric mucosal cells but also that putative physiological agonists regulated release of the peptide.
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