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MicroRNAs (miRNAs) are endogenously expressed small, non-coding transcripts that regulate protein expression.
RNAi-based therapies consist of using small RNA oligonucleotides to regulate protein expression at the post-transcriptional level.
For survival, plants must respond to flood and/or heat stresses differently from the way they regulate protein expression during biochemical and physiological adaptations.
MiRNAs are approximately 21 nucleotide non-coding transcripts that are derived from hairpin precursors, which regulate protein expression by base pairing to the 3′ untranslated region (UTR) of mRNAs (Chen et al., 2008).
Because miRNAs may regulate protein expression by translational inhibition or mRNA degradation or both mechanisms (Hausser and Zavolan, 2014; Vidigal and Ventura, 2015; Wilczynska and Bushell, 2015), these results suggest that miR-130a may decrease the MeCP2 protein level by affecting translation efficiency rather than degrading MeCP2 mRNA.
Differential use of the TrkB IRESes may be a mechanism to regulate protein expression levels.
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Alternative splicing not only regulates protein expression, but also allows multiple proteins to be expressed from the same gene resulting in significant proteomic diversity [9].
Tissue-specific localization of protein expression in B. malayi has been used to confirm gender regulated protein expression and as pointer to protein function[31].
A complex gene network regulates protein expression during grain development [ 26].
It is well known that microRNA negatively regulates protein expression by interacting with the 3′-untranslated regions of specific mRNA.
Thus, the RNA duplexes having the thymidine dimers with the carbamate or urea linkage at their 3′ overhang regions will be promising candidates for novel siRNA molecules to down-regulate protein expression.
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